Across TCGA pan-cancer cohorts, MPHOSPH8 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MPHOSPH8 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MPHOSPH8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MPHOSPH8 expression acts as an unfavorable survival marker, although some lineages such as COAD and GBM show a favorable association.

HNSC, COAD, and UCEC are the cancer types where MPHOSPH8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.781	0.956	<.001	39	view →
COAD	DFS	Tertile	All	1.000	0.853	.033	12	view →
UCEC	DFS	Tertile	II,III,IV	0.540	1.000	.012	8	view →
PDAC	DFS	Median	III,IV	0.179	0.494	.018	7	view →
GBM	OS	Tertile	All	0.567	0.302	.037	3	view →
LUAD	DFS	Tertile	All	1.000	0.856	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: MPHOSPH8 tumor-vs-normal RNA expression · all MPHOSPH8 data types