Across TCGA patient cohorts, MPHOSPH8 mutation is significantly associated with the RNA expression of many other genes, with 3,458 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPHOSPH8-associated genes across cancer lineages are BUB3, LSM3, and MRPS22. Each is linked with MPHOSPH8 in more than 2 cancer types. Because this analysis shows association rather than direction, both MPHOSPH8-to-partner and partner-to-MPHOSPH8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPHOSPH8→partner) and Y-score (partner→MPHOSPH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.471	+2.577	<.001	<.001	3	3
UCEC	LSM3 →	+0.519	+3.115	<.001	<.001	3	3
UCEC	MRPS22 →	+0.297	+1.960	.006	<.001	3	3
UCEC	RAD18 →	+0.448	+3.043	<.001	<.001	3	3
UCEC	ACBD5 →	+0.519	+2.643	.001	<.001	3	3
UCEC	CENPK →	+0.773	+2.643	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,458 associations by consensus.

Exploration

MPHOSPH8 survival (RNA) · tumor vs normal (RNA) · all MPHOSPH8 data types