MPHOSPH8

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, MPHOSPH8 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPHOSPH8-associated genes across cancer lineages are Caspase-7-cleavedD198, FoxM1, and p62 Lck ligand. Each is linked with MPHOSPH8 in more than 2 cancer types. Because this analysis shows association rather than direction, both MPHOSPH8-to-partner and partner-to-MPHOSPH8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPHOSPH8→partner) and Y-score (partner→MPHOSPH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCaspase-7-cleavedD198 →+0.524+2.115.012.01633
UCECFoxM1 →+0.182+2.392.047<.00132
UCECp62 Lck ligand →+0.370+2.916.001<.00132
UCECSTAT3_pY705 →-0.302-1.662.001.01132
UCECCaspase-8 →-0.240-1.780.006.02432
UCEC4E-BP1 →+0.270+1.936.004.00832
Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

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