Across TCGA cell cohorts, MPHOSPH8 mutation is significantly associated with the RNA expression of many other genes, with 99 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MPHOSPH8-associated genes across cancer lineages are CLEC4E, DEFB132, and KRTAP10-8. Each is linked with MPHOSPH8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPHOSPH8-to-partner and partner-to-MPHOSPH8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPHOSPH8→partner) and Y-score (partner→MPHOSPH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CLEC4E →	+0.105	+4.169	<.001	.008	3	1
CNS	DEFB132 →	+0.324	+4.321	<.001	.009	3	1
CNS	KRTAP10-8 →	+0.025	+5.357	<.001	.001	3	1
BLOOD_Leukemia	PRSS54 →	+0.027	+4.539	<.001	.007	3	1
BLOOD_Leukemia	CST2 →	+0.348	+4.152	<.001	.009	3	1
BLOOD_Leukemia	OR1A2 →	+0.027	+5.569	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

Exploration

MPHOSPH8 survival (RNA) · tumor vs normal (RNA) · all MPHOSPH8 data types