MPG

Across TCGA pan-cancer cohorts, MPG mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MPG data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MPG mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MPG expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

COAD, LUAD, and GBM are the cancer types where MPG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	III,IV	0.881	1.000	.035	18	view →
LUAD	OS	Tertile	All	1.000	0.734	.012	6	view →
GBM	OS	Quartile	All	0.571	0.318	.023	6	view →
PDAC	OS	Median	II,III,IV	0.443	0.598	.026	6	view →
LSCC	OS	Median	All	0.872	0.724	.041	1	view →
HNSC	OS	Median	All	0.803	0.892	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MPG–COAD (DFS)

Open the COAD breakdown →