MPG

Across TCGA patient cohorts, MPG mutation is significantly associated with the RNA expression of many other genes, with 155 significant associations in total. STAD shows the largest number of these associations.

The most reproducible MPG-associated genes across cancer lineages are LYPLA1P1, RNU6-296P, and RPSAP35. Each is linked with MPG in more than 1 cancer types. Because this analysis shows association rather than direction, both MPG-to-partner and partner-to-MPG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYPLA1P1 grouped by MPG-low versus MPG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPG→partner) and Y-score (partner→MPG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LYPLA1P1 →	+0.076	+4.049	<.001	.008	3	2
STAD	RNU6-296P →	+0.337	+5.026	.001	.009	3	2
STAD	RPSAP35 →	+0.237	+5.678	<.001	.003	3	2
STAD	LINC02509 →	+0.226	+5.274	<.001	.006	3	2
COAD	SLC20A1P3 →	+0.092	+5.917	<.001	.001	3	2
LGG	RNU6-66P →	+0.328	+7.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 155 associations by consensus.

LYPLA1P1 by MPG expression — UCEC

Explore this box plot interactively →