Across TCGA pan-cancer cohorts, MPEG1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MPEG1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MPEG1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MPEG1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where MPEG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.927	0.563	.017	21	view →
LUAD	OS	Tertile	III,IV	0.643	0.996	.018	13	view →
PDAC	OS	Median	IV	0.437	0.828	.038	3	view →
LSCC	OS	Median	III,IV	0.925	0.789	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: MPEG1 tumor-vs-normal RNA expression · all MPEG1 data types