Across TCGA patient cohorts, MPEG1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPEG1-associated genes across cancer lineages are 14-3-3_beta, mTOR_pS2448, and GAPDH. Each is linked with MPEG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MPEG1-to-partner and partner-to-MPEG1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPEG1→partner) and Y-score (partner→MPEG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.086	-1.780	.013	.024	3	3
UCEC	mTOR_pS2448 →	-0.126	-2.102	.014	.016	3	3
UCEC	GAPDH →	+0.521	+1.736	.005	.007	3	2
UCEC	INPP4B →	-0.243	-1.765	.030	.013	3	2
UCEC	JNK_pT183_Y185 →	-0.195	-2.584	<.001	.010	3	2
UCEC	p21 →	+0.172	+1.736	.009	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Exploration

MPEG1 survival (RNA) · tumor vs normal (RNA) · all MPEG1 data types