MPDU1

Across TCGA patient cohorts, MPDU1 mutation is significantly associated with the RNA expression of many other genes, with 585 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPDU1-associated genes across cancer lineages are NF1P10, MIR4290HG, and ZSWIM5P1. Each is linked with MPDU1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPDU1-to-partner and partner-to-MPDU1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF1P10 grouped by MPDU1-low versus MPDU1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPDU1→partner) and Y-score (partner→MPDU1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF1P10 →	+0.168	+2.971	<.001	<.001	3	2
BLCA	MIR4290HG →	+0.024	+5.251	.001	.006	3	1
BLCA	ZSWIM5P1 →	+0.035	+6.147	<.001	.002	3	1
UCEC	EI24 →	+0.533	+3.584	.008	.003	3	1
UCEC	VPS26B →	+0.522	+3.606	.002	.001	3	1
UCEC	SLC25A4 →	+0.753	+3.595	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 585 associations by consensus.

NF1P10 by MPDU1 expression — UCEC

Explore this box plot interactively →