MPC2

Across TCGA patient cohorts, MPC2 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPC2-associated genes across cancer lineages are MIR6124, IL21, and MIR3193. Each is linked with MPC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MPC2-to-partner and partner-to-MPC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6124 grouped by MPC2-low versus MPC2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPC2→partner) and Y-score (partner→MPC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR6124 →	+0.526	+5.302	<.001	.001	3	1
UCEC	IL21 →	+0.231	+2.763	<.001	.009	3	1
UCEC	MIR3193 →	+0.761	+2.838	<.001	.009	3	1
UCEC	MIR5188 →	+0.648	+3.235	.001	.003	3	1
SKCM	NME1P1 →	+0.150	+6.485	<.001	<.001	3	1
SKCM	RPL34P21 →	+0.376	+4.628	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

MIR6124 by MPC2 expression — SKCM

Explore this box plot interactively →