MPC1L

Across TCGA patient cohorts, MPC1L RNA expression is significantly associated with the go_rna of many other GO terms, with 6,012 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible MPC1L-associated GO terms across cancer lineages are Pyruvate transport, Regulation of mitochondrial transcription, and Iron-sulfur cluster assembly. Each is linked with MPC1L in more than 9 cancer types. Because this analysis shows association rather than direction, both MPC1L-to-partner and partner-to-MPC1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pyruvate transport grouped by MPC1L-low versus MPC1L-high in UCEC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MPC1L→partner) and Y-score (partner→MPC1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Pyruvate transport →	-0.064	-0.629	<.001	<.001	3	10
TGCT	Regulation of mitochondrial transcription →	+0.041	+1.282	<.001	<.001	3	5
TGCT	Iron-sulfur cluster assembly →	+0.033	+1.686	<.001	<.001	3	5
TGCT	Positive regulation of synapse assembly →	-0.037	-1.450	<.001	<.001	3	5
UCEC	Negative regulation of protein localization to chromatin →	+0.028	+0.323	<.001	<.001	3	5
ESCA	Positive regulation by symbiont of entry into host →	+0.050	+0.123	.003	.003	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,012 associations by consensus.

Pyruvate transport by MPC1L expression — UCEC

Explore this box plot interactively →