MOV10

Across TCGA pan-cancer cohorts, MOV10 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MOV10 data layer compared with 21 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MOV10 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MOV10 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and GBM are the cancer types where MOV10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.843	0.597	.011	8	view →
PDAC	OS	Tertile	IV	0.962	0.425	.024	6	view →
GBM	DFS	Quartile	All	0.600	0.880	.005	2	view →
LUAD	OS	Tertile	All	0.671	1.000	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MOV10–HNSC (OS)

Open the HNSC breakdown →