MOV10

Across TCGA patient cohorts, MOV10 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOV10-associated genes across cancer lineages are MEK1, PEA-15_pS116, and ATM. Each is linked with MOV10 in more than 1 cancer types. Because this analysis shows association rather than direction, both MOV10-to-partner and partner-to-MOV10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by MOV10-low versus MOV10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOV10→partner) and Y-score (partner→MOV10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.368	+3.584	.017	.002	3	2
UCEC	PEA-15_pS116 →	+0.382	+2.222	.010	.011	3	2
UCEC	ATM →	-0.581	-2.222	.002	.011	3	2
UCEC	Di-Ras3 →	-0.189	-2.906	.002	.001	3	2
SKCM	STAT3_pY705 →	-0.360	-2.966	.010	.034	3	2
COAD	PDCD4 →	-0.474	-3.000	.016	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

MEK1 by MOV10 expression — UCEC

Explore this box plot interactively →