MOV10

Across TCGA cell cohorts, MOV10 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MOV10-associated genes across cancer lineages are GABRA6, IFNA14, and C14orf177. Each is linked with MOV10 in more than 1 cancer types. Because this analysis shows association rather than direction, both MOV10-to-partner and partner-to-MOV10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GABRA6 grouped by MOV10-low versus MOV10-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOV10→partner) and Y-score (partner→MOV10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GABRA6 →	+0.066	+4.189	<.001	.002	3	2
SOFT_TISSUE	IFNA14 →	+0.032	+5.369	<.001	.004	3	1
BLOOD_Leukemia	C14orf177 →	+0.076	+4.922	<.001	.009	3	1
LARGE_INTESTINE	C2orf42 →	+0.609	+3.215	.001	.009	3	1
LARGE_INTESTINE	GALR3 →	+0.105	+3.424	<.001	.006	3	1
LARGE_INTESTINE	ADPRM →	+0.629	+3.067	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

GABRA6 by MOV10 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →