MOSPD3

Across TCGA pan-cancer cohorts, MOSPD3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MOSPD3 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MOSPD3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MOSPD3 expression acts as an unfavorable survival marker, although some lineages such as UVM and ESCA show a favorable association.

ACC, KICH, and LGG are the cancer types where MOSPD3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.166	0.720	<.001	57	view →
KICH	OS	Tertile	II,III,IV	0.424	1.000	.004	44	view →
LGG	OS	Median	All	0.732	0.878	<.001	36	view →
UVM	DFS	Median	All	0.715	0.449	.004	30	view →
READ	DFS	Median	II,III,IV	0.325	0.666	.002	23	view →
CESC	DFS	Quartile	All	0.432	0.716	.003	22	view →
SCLC	OS	Tertile	All	0.293	0.553	.021	20	view →
ESCA	OS	Tertile	All	0.824	0.634	.015	13	view →
COAD	OS	Tertile	All	0.764	0.869	.023	13	view →
KIRP	DFS	Median	III,IV	0.653	0.223	.013	11	view →
GBM	OS	Tertile	All	0.146	0.253	.007	11	view →
HNSC	DFS	Tertile	III,IV	0.656	0.411	.021	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

MOSPD3–ACC (DFS)

Open the ACC breakdown →