MOSPD2

Across TCGA patient cohorts, MOSPD2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOSPD2-associated genes across cancer lineages are A-Raf_pS299, ERK2, and Src_pY416. Each is linked with MOSPD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MOSPD2-to-partner and partner-to-MOSPD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by MOSPD2-low versus MOSPD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOSPD2→partner) and Y-score (partner→MOSPD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.104	-1.662	.013	.011	3	2
UCEC	ERK2 →	+0.207	+2.459	.002	.018	3	2
UCEC	Src_pY416 →	-0.200	-3.143	.019	.018	3	2
UCEC	ASNS →	+0.498	+2.087	<.001	.005	3	2
UCEC	Di-Ras3 →	-0.122	-2.571	.019	.010	3	2
UCEC	EGFR_pY1068 →	-0.262	-2.000	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

A-Raf_pS299 by MOSPD2 expression — UCEC

Explore this box plot interactively →