MOSPD1

Across TCGA patient cohorts, MOSPD1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOSPD1-associated genes across cancer lineages are Notch1, 14-3-3_beta, and eEF2. Each is linked with MOSPD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MOSPD1-to-partner and partner-to-MOSPD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MOSPD1-low versus MOSPD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOSPD1→partner) and Y-score (partner→MOSPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.138	+2.235	.004	.005	3	2
UCEC	14-3-3_beta →	-0.102	-2.673	.002	.005	3	1
UCEC	eEF2 →	+0.339	+3.321	.005	.009	3	1
UCEC	EGFR_pY1068 →	-0.263	-2.137	.002	.001	3	1
UCEC	eIF4G →	+0.273	+1.807	.009	.004	3	1
UCEC	A-Raf_pS299 →	-0.133	-2.115	.001	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Notch1 by MOSPD1 expression — UCEC

Explore this box plot interactively →