MORF4L2

Across TCGA patient cohorts, MORF4L2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MORF4L2-associated genes across cancer lineages are S6_pS240_S244, A-Raf_pS299, and FOXO3a. Each is linked with MORF4L2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MORF4L2-to-partner and partner-to-MORF4L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by MORF4L2-low versus MORF4L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MORF4L2→partner) and Y-score (partner→MORF4L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.321	+2.584	.039	.001	3	2
UCEC	A-Raf_pS299 →	-0.128	-2.000	.005	.030	3	1
UCEC	FOXO3a →	-0.112	-2.074	.004	.005	3	1
UCEC	Heregulin →	-0.136	-1.678	.004	.023	3	1
UCEC	JNK2 →	+0.221	+3.611	.003	.001	3	1
UCEC	MEK1 →	+0.328	+2.222	.019	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

S6_pS240_S244 by MORF4L2 expression — UCEC

Explore this box plot interactively →