Across TCGA pan-cancer cohorts, MORF4L1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MORF4L1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MORF4L1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MORF4L1 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

HNSC, GBM, and CCRCC are the cancer types where MORF4L1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.237	0.827	.006	14	view →
GBM	OS	Tertile	All	0.568	0.297	.010	4	view →
CCRCC	OS	Quartile	All	0.913	1.000	.036	2	view →
LSCC	OS	Median	II,III,IV	0.863	0.696	.045	1	view →
LUAD	DFS	Median	II,III,IV	0.773	0.927	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: MORF4L1 tumor-vs-normal RNA expression · all MORF4L1 data types