MORC3

Across TCGA pan-cancer cohorts, MORC3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MORC3 data layer compared with 26 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher MORC3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MORC3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, READ, and SKCM are the cancer types where MORC3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
READ	OS	Median	All	0.281	0.830	.006	3	view →
SKCM	OS	Median	III,IV	0.245	0.721	.018	3	view →
UCEC	OS	Median	II,III,IV	0.915	0.462	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MORC3–THYM (OS)

Open the THYM breakdown →