MORC3

Across TCGA pan-cancer cohorts, MORC3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MORC3 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MORC3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MORC3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and UCEC are the cancer types where MORC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.773	0.398	.003	37	view →
PDAC	DFS	Median	All	0.971	0.640	<.001	35	view →
UCEC	DFS	Quartile	II,III,IV	0.319	1.000	.004	32	view →
HNSC	OS	Tertile	All	1.000	0.277	.013	29	view →
CCRCC	OS	Median	II,III,IV	0.730	0.915	.013	14	view →
LSCC	DFS	Median	II,III,IV	0.968	0.878	.017	4	view →
GBM	OS	Tertile	All	0.522	0.298	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MORC3–LUAD (DFS)

Open the LUAD breakdown →