MORC3

Across TCGA patient cohorts, MORC3 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MORC3-associated genes across cancer lineages are eEF2, EGFR_pY1068, and Shc_pY317. Each is linked with MORC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MORC3-to-partner and partner-to-MORC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by MORC3-low versus MORC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MORC3→partner) and Y-score (partner→MORC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.277	+2.000	.023	.029	3	2
UCEC	EGFR_pY1068 →	-0.295	-2.523	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.216	-2.137	<.001	.001	3	2
UCEC	TFRC →	+0.534	+1.807	.003	.004	3	2
UCEC	ASNS →	+0.395	+1.765	.001	.013	3	2
UCEC	Bax →	+0.245	+1.688	.002	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

eEF2 by MORC3 expression — UCEC

Explore this box plot interactively →