MORC3

Across TCGA cell cohorts, MORC3 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MORC3-associated genes across cancer lineages are LHCGR, ELANE, and DAZ2. Each is linked with MORC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MORC3-to-partner and partner-to-MORC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LHCGR grouped by MORC3-low versus MORC3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MORC3→partner) and Y-score (partner→MORC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LHCGR →	+0.029	+3.297	.002	.002	3	1
LARGE_INTESTINE	ELANE →	+0.312	+3.404	<.001	.006	3	1
LARGE_INTESTINE	DAZ2 →	+0.145	+4.000	.002	<.001	3	1
LARGE_INTESTINE	RBMY1J →	+0.005	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR6Q1 →	+0.012	+3.700	<.001	.009	3	1
LARGE_INTESTINE	SMIM33 →	+0.637	+3.426	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

LHCGR by MORC3 expression — LARGE_INTESTINE

Explore this box plot interactively →