MON2

Across TCGA pan-cancer cohorts, MON2 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MON2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MON2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MON2 is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

COAD, LUAD, and HNSC are the cancer types where MON2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MON2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−0.174	<.001	11	view →
LUAD	Male	III,IV	+0.232	<.001	9	view →
HNSC	All	IV	+0.148	.006	9	view →
LSCC	Male	III,IV	+0.246	<.001	7	view →
PDAC	Female	All	−0.237	.004	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MON2–COAD

Open the COAD breakdown →