MON2

Across TCGA patient cohorts, MON2 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MON2-associated genes across cancer lineages are FASN, PCNA, and Shc_pY317. Each is linked with MON2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MON2-to-partner and partner-to-MON2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by MON2-low versus MON2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MON2→partner) and Y-score (partner→MON2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.270	+1.222	.016	.011	3	4
UCEC	PCNA →	+0.165	+1.321	.007	.027	3	3
COAD	Shc_pY317 →	-0.187	-3.157	.010	.018	3	3
COAD	Caspase-7-cleavedD198 →	+1.015	+2.467	.003	.011	3	3
UCEC	Cyclin-B1 →	+0.583	+1.584	<.001	.001	3	3
LUSC	p53 →	-0.355	-3.160	.032	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

FASN by MON2 expression — UCEC

Explore this box plot interactively →