MON2

Across TCGA cell cohorts, MON2 mutation is significantly associated with the RNA expression of many other genes, with 542 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MON2-associated genes across cancer lineages are LANCL1, ATF4, and ACER1. Each is linked with MON2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MON2-to-partner and partner-to-MON2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LANCL1 grouped by MON2-low versus MON2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MON2→partner) and Y-score (partner→MON2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LANCL1 →	+0.737	+2.502	.005	.005	3	2
LARGE_INTESTINE	ATF4 →	+0.632	+3.169	.001	.009	3	2
LARGE_INTESTINE	ACER1 →	+0.067	+2.086	.001	.009	3	2
LARGE_INTESTINE	ERP29 →	+0.455	+2.502	.001	.005	3	2
BLOOD_Leukemia	CARD6 →	-0.963	-3.370	.002	.003	3	2
BLOOD_Lymphoma	OR9K2 →	+0.017	+5.247	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 542 associations by consensus.

LANCL1 by MON2 expression — LARGE_INTESTINE

Explore this box plot interactively →