MON1A

Across TCGA pan-cancer cohorts, MON1A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MON1A data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MON1A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MON1A expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where MON1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.416	0.707	.001	34	view →
CCRCC	DFS	Tertile	II,III,IV	0.749	0.155	.009	14	view →
PDAC	OS	Median	IV	0.405	0.828	.038	3	view →
LUAD	OS	Quartile	All	1.000	0.942	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MON1A–HNSC (DFS)

Open the HNSC breakdown →