MOK

Across TCGA patient cohorts, MOK mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOK-associated genes across cancer lineages are MIG-6, mTOR_pS2448, and PCNA. Each is linked with MOK in more than 1 cancer types. Because this analysis shows association rather than direction, both MOK-to-partner and partner-to-MOK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by MOK-low versus MOK-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOK→partner) and Y-score (partner→MOK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIG-6 →	+0.130	+3.059	.011	.017	3	2
UCEC	mTOR_pS2448 →	-0.148	-2.308	.016	.033	3	2
COAD	PCNA →	+0.466	+3.008	<.001	.019	3	2
UCEC	PDCD4 →	-0.736	-3.459	<.001	.005	3	2
UCEC	TIGAR →	+0.128	+2.348	.042	.003	3	2
UCEC	Caveolin-1 →	-0.669	-2.459	.025	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

MIG-6 by MOK expression — COAD

Explore this box plot interactively →