MOGS

Across TCGA patient cohorts, MOGS mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. COAD shows the largest number of these associations.

The most reproducible MOGS-associated genes across cancer lineages are TSC1, MEK1, and Smad4. Each is linked with MOGS in more than 2 cancer types. Because this analysis shows association rather than direction, both MOGS-to-partner and partner-to-MOGS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSC1 grouped by MOGS-low versus MOGS-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOGS→partner) and Y-score (partner→MOGS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TSC1 →	-0.372	-2.321	.001	.033	3	3
COAD	MEK1 →	+0.232	+1.900	.005	.030	3	2
COAD	Smad4 →	+0.130	+3.000	.019	.034	3	2
COAD	Caspase-7-cleavedD198 →	+0.817	+3.169	.013	.018	3	2
COAD	CDK1 →	+0.235	+2.593	.001	.006	3	2
COAD	Claudin-7 →	+0.569	+3.000	.041	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

TSC1 by MOGS expression — COAD

Explore this box plot interactively →