MOGS

Across TCGA cell cohorts, MOGS mutation is significantly associated with the drug of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MOGS-associated genes across cancer lineages are Uprosertib, Luminespib, and AZD5153. Each is linked with MOGS in more than 1 cancer types. Because this analysis shows association rather than direction, both MOGS-to-partner and partner-to-MOGS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Uprosertib grouped by MOGS-low versus MOGS-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOGS→partner) and Y-score (partner→MOGS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Uprosertib →	+0.608	+3.061	.026	.010	3	1
LARGE_INTESTINE	Luminespib →	+0.636	+3.061	.020	.010	3	1
LARGE_INTESTINE	AZD5153 →	+0.612	+3.064	.006	.009	3	1
LARGE_INTESTINE	CDK9_5038 →	+0.550	+2.807	.027	.035	3	1
LARGE_INTESTINE	IRAK4_4710 →	+0.447	+2.710	.005	.027	3	1
LARGE_INTESTINE	JAK1_8709 →	+0.557	+3.064	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Uprosertib by MOGS expression — LARGE_INTESTINE

Explore this box plot interactively →