MOGAT3

Across TCGA patient cohorts, MOGAT3 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOGAT3-associated genes across cancer lineages are JNK_pT183_Y185, mTOR_pS2448, and Notch1. Each is linked with MOGAT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MOGAT3-to-partner and partner-to-MOGAT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by MOGAT3-low versus MOGAT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOGAT3→partner) and Y-score (partner→MOGAT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.172	-2.700	.009	.006	3	1
UCEC	mTOR_pS2448 →	-0.182	-3.571	.001	.002	3	1
UCEC	Notch1 →	+0.229	+2.817	<.001	.001	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.610	-2.807	<.001	.003	3	1
UCEC	PDCD4 →	-0.450	-1.584	.014	.036	3	1
UCEC	PKC-b-II_pS660 →	-0.264	-1.584	.015	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

JNK_pT183_Y185 by MOGAT3 expression — UCEC

Explore this box plot interactively →