MOGAT3

Across TCGA cell cohorts, MOGAT3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MOGAT3-associated genes across cancer lineages are MS4A4A, CLPS, and TKTL2. Each is linked with MOGAT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MOGAT3-to-partner and partner-to-MOGAT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A4A grouped by MOGAT3-low versus MOGAT3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOGAT3→partner) and Y-score (partner→MOGAT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MS4A4A →	+0.185	+4.000	<.001	.002	3	1
LARGE_INTESTINE	CLPS →	+0.541	+3.688	<.001	.002	3	1
LARGE_INTESTINE	TKTL2 →	+0.054	+4.187	<.001	.002	3	1
LARGE_INTESTINE	NEXMIF →	+0.264	+3.196	<.001	.007	3	1
SKIN	PRSS51 →	+0.227	+3.617	.002	.004	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MS4A4A by MOGAT3 expression — LARGE_INTESTINE

Explore this box plot interactively →