Across TCGA patient cohorts, MOG mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOG-associated genes across cancer lineages are 4E-BP1, eEF2, and EGFR_pY1068. Each is linked with MOG in more than 2 cancer types. Because this analysis shows association rather than direction, both MOG-to-partner and partner-to-MOG results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOG→partner) and Y-score (partner→MOG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.291	+2.351	.009	.018	3	3
UCEC	eEF2 →	+0.308	+1.807	.037	.027	3	2
UCEC	EGFR_pY1068 →	-0.319	-4.087	.002	<.001	3	2
UCEC	A-Raf_pS299 →	-0.138	-3.321	.005	.010	3	2
UCEC	FOXO3a_pS318_S321 →	-0.135	-3.575	.008	.002	3	2
UCEC	GATA6 →	-0.154	-2.899	.019	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Exploration

MOG survival (RNA) · tumor vs normal (RNA) · all MOG data types