Across TCGA cell cohorts, MOG mutation is significantly associated with the mutation status of many other genes, with 278 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MOG-associated genes across cancer lineages are PDE8B, CHRM3, and PPM1H. Each is linked with MOG in more than 1 cancer types. Because this analysis shows association rather than direction, both MOG-to-partner and partner-to-MOG results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOG→partner) and Y-score (partner→MOG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PDE8B →	+5.066	+4.502	.007	.007	1	2
LUNG_SCLC	CHRM3 →	+3.066	+4.369	.005	.005	1	2
BLOOD_Lymphoma	PPM1H →	+4.584	+4.584	.007	.007	1	2
BLOOD_Lymphoma	DCAF8 →	+5.584	+5.014	.003	.003	1	2
BLOOD_Lymphoma	PDE3B →	+4.169	+5.316	<.001	<.001	1	2
BLOOD_Lymphoma	MIA3 →	+3.362	+4.754	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 278 associations by consensus.

Exploration

MOG survival (RNA) · tumor vs normal (RNA) · all MOG data types