MOCS3

Across TCGA pan-cancer cohorts, MOCS3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MOCS3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MOCS3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MOCS3 is over-expressed in tumor.

COAD, KIRP, and KIRC are the cancer types where MOCS3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MOCS3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.213	<.001	11	view →
KIRP	Male	II,III,IV	+1.037	<.001	11	view →
KIRC	Male	All	+0.483	<.001	11	view →
HNSC	Male	All	+0.693	<.001	10	view →
BLCA	Male	All	+0.848	<.001	9	view →
LIHC	Male	II,III,IV	+0.743	<.001	9	view →
STAD	All	II,III,IV	+0.878	<.001	8	view →
LUAD	Male	All	+0.430	<.001	8	view →
LUSC	Male	II,III,IV	+0.891	<.001	7	view →
BRCA	All	III,IV	+0.907	<.001	6	view →
CHOL	Male	All	+1.460	<.001	5	view →
READ	All	All	+0.829	.002	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MOCS3–COAD

Open the COAD breakdown →