MOCOS

Across TCGA patient cohorts, MOCOS mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOCOS-associated genes across cancer lineages are FoxM1, INPP4B, and Caspase-8. Each is linked with MOCOS in more than 1 cancer types. Because this analysis shows association rather than direction, both MOCOS-to-partner and partner-to-MOCOS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by MOCOS-low versus MOCOS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOCOS→partner) and Y-score (partner→MOCOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.190	+1.502	.046	.030	3	2
UCEC	INPP4B →	-0.272	-2.459	.022	.018	3	2
UCEC	Caspase-8 →	-0.250	-2.880	.006	.001	3	2
UCEC	c-Met_pY1235 →	+0.054	+1.775	.048	.007	3	2
UCEC	4E-BP1 →	+0.211	+3.351	.034	.005	3	2
UCEC	C-Raf_pS338 →	-0.069	-1.502	.022	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

FoxM1 by MOCOS expression — UCEC

Explore this box plot interactively →