MOCOS

Across TCGA cell cohorts, MOCOS mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MOCOS-associated genes across cancer lineages are NEUROG3, CLEC4C, and MS4A7. Each is linked with MOCOS in more than 1 cancer types. Because this analysis shows association rather than direction, both MOCOS-to-partner and partner-to-MOCOS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEUROG3 grouped by MOCOS-low versus MOCOS-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOCOS→partner) and Y-score (partner→MOCOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NEUROG3 →	+0.185	+4.643	<.001	.003	3	1
BREAST	CLEC4C →	+0.019	+5.169	<.001	.005	3	1
LARGE_INTESTINE	MS4A7 →	+0.034	+3.464	.001	.004	3	1
LARGE_INTESTINE	MROH2A →	+0.524	+3.228	<.001	.009	3	1
BLOOD_Leukemia	FSHB →	+0.002	+4.247	<.001	.004	3	1
BLOOD_Leukemia	CPA2 →	+0.165	+3.518	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

NEUROG3 by MOCOS expression — CNS

Explore this box plot interactively →