MOB3A

Across TCGA pan-cancer cohorts, MOB3A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MOB3A data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MOB3A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MOB3A expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

CCRCC, HNSC, and UCEC are the cancer types where MOB3A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	II,III,IV	0.389	0.815	.002	39	view →
HNSC	DFS	Median	III,IV	0.692	0.897	.002	14	view →
UCEC	DFS	Tertile	All	0.779	0.973	.010	12	view →
COAD	DFS	Median	III,IV	0.811	1.000	.042	6	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	3	view →
GBM	OS	Median	All	0.628	0.440	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MOB3A–CCRCC (DFS)

Open the CCRCC breakdown →