MOB3A

Across TCGA patient cohorts, MOB3A mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOB3A-associated genes across cancer lineages are ATM, JNK_pT183_Y185, and JNK2. Each is linked with MOB3A in more than 2 cancer types. Because this analysis shows association rather than direction, both MOB3A-to-partner and partner-to-MOB3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MOB3A-low versus MOB3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOB3A→partner) and Y-score (partner→MOB3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.582	-2.000	.004	.032	2	3
UCEC	JNK_pT183_Y185 →	-0.163	-2.321	.031	.034	3	1
UCEC	JNK2 →	+0.345	+3.807	<.001	<.001	3	1
UCEC	Ku80 →	+0.247	+2.013	.020	.018	3	1
UCEC	MEK1 →	+0.493	+3.459	.002	.005	3	1
UCEC	MSH2 →	-0.419	-3.449	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ATM by MOB3A expression — UCEC

Explore this box plot interactively →