MOB3A

Across TCGA cell cohorts, MOB3A mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MOB3A-associated genes across cancer lineages are GFRA4, CSN2, and KRT85. Each is linked with MOB3A in more than 1 cancer types. Because this analysis shows association rather than direction, both MOB3A-to-partner and partner-to-MOB3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by MOB3A-low versus MOB3A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOB3A→partner) and Y-score (partner→MOB3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GFRA4 →	+0.023	+3.930	<.001	.003	3	2
LARGE_INTESTINE	CSN2 →	+0.031	+3.684	<.001	.006	3	1
LARGE_INTESTINE	KRT85 →	+0.527	+3.823	<.001	.006	3	1
LARGE_INTESTINE	OR6B2 →	+0.056	+4.054	<.001	.004	3	1
LARGE_INTESTINE	OR2J1 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	TEX53 →	+0.098	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

GFRA4 by MOB3A expression — LARGE_INTESTINE

Explore this box plot interactively →