MOAP1

Across TCGA patient cohorts, MOAP1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MOAP1-associated genes across cancer lineages are NF2, Caspase-7-cleavedD198, and Caspase-8. Each is linked with MOAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MOAP1-to-partner and partner-to-MOAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by MOAP1-low versus MOAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MOAP1→partner) and Y-score (partner→MOAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF2 →	+0.235	+2.321	.013	.034	3	2
UCEC	Caspase-7-cleavedD198 →	+0.801	+2.807	.001	.003	3	2
UCEC	Caspase-8 →	-0.311	-2.807	.004	.003	3	2
UCEC	eIF4E →	+0.186	+2.807	.044	.003	3	1
UCEC	FoxM1 →	+0.263	+2.115	.020	.019	3	1
UCEC	ACVRL1 →	-0.169	-2.095	.004	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

NF2 by MOAP1 expression — UCEC

Explore this box plot interactively →