MNT

Across TCGA pan-cancer cohorts, MNT mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MNT data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MNT mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MNT expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC, UCEC, and LSCC are the cancer types where MNT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.728	0.322	.002	14	view →
UCEC	DFS	Tertile	III,IV	0.510	1.000	.049	4	view →
LSCC	DFS	Median	III,IV	0.868	1.000	.027	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MNT–PDAC (OS)

Open the PDAC breakdown →