MNT

Across TCGA pan-cancer cohorts, MNT mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MNT’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where MNT mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types MNT is over-expressed in tumor.

CCRCC and LSCC are the cancer types where MNT tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MNT mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	All	+0.345	<.001	6	view →
LSCC	Male	All	+0.172	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

MNT–CCRCC

Open the CCRCC breakdown →