MNDA

Across TCGA patient cohorts, MNDA mutation is significantly associated with the RNA expression of many other genes, with 1,186 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MNDA-associated genes across cancer lineages are SLC25A5P9, CCL5, and RNU6-879P. Each is linked with MNDA in more than 2 cancer types. Because this analysis shows association rather than direction, both MNDA-to-partner and partner-to-MNDA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A5P9 grouped by MNDA-low versus MNDA-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MNDA→partner) and Y-score (partner→MNDA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	SLC25A5P9 →	+0.135	+3.724	.001	.007	3	3
UCEC	CCL5 →	+0.866	+2.243	.001	<.001	3	2
LIHC	RNU6-879P →	+0.284	+3.589	.005	.004	3	2
LIHC	RNU6-776P →	+0.278	+4.902	<.001	.003	3	2
LIHC	RPL32P35 →	+0.054	+4.305	<.001	.007	3	2
LIHC	MTND6P15 →	+0.046	+5.914	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,186 associations by consensus.

SLC25A5P9 by MNDA expression — READ

Explore this box plot interactively →