MNDA

Across TCGA cell cohorts, MNDA mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MNDA-associated genes across cancer lineages are OR8A1, MMP26, and C20orf85. Each is linked with MNDA in more than 1 cancer types. Because this analysis shows association rather than direction, both MNDA-to-partner and partner-to-MNDA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8A1 grouped by MNDA-low versus MNDA-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MNDA→partner) and Y-score (partner→MNDA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR8A1 →	+0.509	+4.417	<.001	.004	3	2
SKIN	MMP26 →	+0.016	+4.437	<.001	.004	3	2
SOFT_TISSUE	C20orf85 →	+0.086	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR1L4 →	+0.053	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR4D6 →	+0.035	+4.977	<.001	.002	3	1
SOFT_TISSUE	OR51L1 →	+0.027	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

OR8A1 by MNDA expression — SOFT_TISSUE

Explore this box plot interactively →