MND1

Across TCGA patient cohorts, MND1 mutation is significantly associated with the RNA expression of many other genes, with 555 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MND1-associated genes across cancer lineages are DIS3L2P1, KRT8P18, and PPP1R2P5. Each is linked with MND1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MND1-to-partner and partner-to-MND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DIS3L2P1 grouped by MND1-low versus MND1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MND1→partner) and Y-score (partner→MND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DIS3L2P1 →	+0.046	+4.199	<.001	.009	3	2
SKCM	KRT8P18 →	+0.058	+3.551	<.001	.004	3	2
SKCM	PPP1R2P5 →	+0.038	+4.624	<.001	.005	3	2
UCEC	RNU6-271P →	+0.233	+2.977	<.001	.009	3	2
UCEC	MIR378E →	+0.321	+3.579	<.001	.002	3	2
SKCM	SLC6A14P3 →	+0.816	+3.962	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 555 associations by consensus.

DIS3L2P1 by MND1 expression — SKCM

Explore this box plot interactively →