MNAT1

Across TCGA pan-cancer cohorts, MNAT1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MNAT1 data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher MNAT1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MNAT1 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

SKCM, UCEC, and LUSC are the cancer types where MNAT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.230	0.783	.002	30	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUSC	OS	Median	II,III,IV	0.173	0.677	.029	3	view →
BRCA	DFS	Median	All	0.642	0.949	.031	3	view →
BLCA	DFS	Median	All	1.000	0.327	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MNAT1–SKCM (OS)

Open the SKCM breakdown →