MNAT1

Across TCGA patient cohorts, MNAT1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MNAT1-associated genes across cancer lineages are MEK1, p62 Lck ligand, and STAT3_pY705. Each is linked with MNAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MNAT1-to-partner and partner-to-MNAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by MNAT1-low versus MNAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MNAT1→partner) and Y-score (partner→MNAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.431	+3.321	.024	.010	3	1
UCEC	p62 Lck ligand →	+0.424	+2.817	.012	.036	2	2
UCEC	STAT3_pY705 →	-0.515	-3.321	<.001	.010	3	1
UCEC	Caspase-8 →	-0.340	-3.321	.009	.010	3	1
UCEC	C-Raf →	+0.219	+3.000	.003	.036	3	1
UCEC	Cyclin-E2 →	+0.197	+2.817	.025	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MEK1 by MNAT1 expression — UCEC

Explore this box plot interactively →