MN1

Across TCGA patient cohorts, MN1 mutation is significantly associated with the RNA expression of many other genes, with 4,108 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MN1-associated genes across cancer lineages are ZWINT, NUSAP1, and VDAC1. Each is linked with MN1 in more than 4 cancer types. Because this analysis shows association rather than direction, both MN1-to-partner and partner-to-MN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWINT grouped by MN1-low versus MN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MN1→partner) and Y-score (partner→MN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWINT →	+0.609	+2.050	<.001	<.001	3	5
UCEC	NUSAP1 →	+0.643	+2.917	<.001	<.001	3	5
UCEC	VDAC1 →	+0.350	+2.513	.003	<.001	3	5
UCEC	GRPEL1 →	+0.453	+2.321	<.001	<.001	3	4
COAD	COX7A2 →	+0.562	+3.611	<.001	.001	3	4
COAD	PPA2 →	+0.531	+3.598	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,108 associations by consensus.

ZWINT by MN1 expression — UCEC

Explore this box plot interactively →