MN1

Across TCGA patient cohorts, MN1 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MN1-associated genes across cancer lineages are PCNA, PDCD4, and mTOR_pS2448. Each is linked with MN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MN1-to-partner and partner-to-MN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MN1-low versus MN1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MN1→partner) and Y-score (partner→MN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.292	+3.012	.012	.018	3	4
STAD	PDCD4 →	-0.434	-3.000	.029	.034	3	4
UCEC	mTOR_pS2448 →	-0.116	-1.565	.020	.034	3	4
LUAD	beta-Catenin →	-0.541	-3.169	.030	.018	3	3
STAD	FASN →	+0.506	+2.321	.006	.034	3	3
COAD	ASNS →	+0.558	+3.330	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

PCNA by MN1 expression — COAD

Explore this box plot interactively →